Gout is a metabolic disease marked by a painful inflammation of the joints, deposits of urates in and around the joints, and usually an excessive amount of uric acid in the blood.
Uric acid is constantly produced and excreted in the body, so it maintains a certain concentration in the blood. The uric acid of blood in normal people is less than 0.42 mmol/L in men and no more than 0.357 mmol/L in women. In the process of purine synthesis and decomposition, a variety of enzymes are involved. Due to congenital abnormalities of enzymes or some unclear factors, metabolism is disordered, resulting in increased synthesis or decreased excretion of uric acid, which can lead to hyperuricemia. When the uric acid concentration in blood is too high, uric acid is in the form of sodium salt.It is deposited in joints, soft tissues, cartilage and kidneys, causing foreign body inflammatory reaction of tissues, which has become the bane of gout.
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