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The combined detection kit of pepsinogen I/ pepsinogen II (time-resolved fluorescence immunoassay) is suitable for quantitative determination of pepsinogen I、 pepsinogen in human serum, plasma and whole blood in vitro.Detection of pepsinogen I (PG I) & II (PG II) simultaneously in one-single test, and calculating the ratio of PGI/PGII can assistant to diagnosis and therapeutic monitoring of chronic atrophic gastritis, gastric ulcer, and duodenal ulcer.
Intended use
The combined detection kit of pepsinogen I/ pepsinogen II (time-resolved fluorescence immunoassay) is suitable for quantitative determination of pepsinogen I、 pepsinogen in human serum, plasma and whole blood in vitro.
Product Information
|
Production name |
Test samples |
Specifications |
|
Pepsinogen I&II Quantitative Test Kit (TRFIA) |
serum/plasma/whole blood |
20T/Kit, 50T/Kit |
Storage Conditions and Expiry Date
The kit is stored in 2℃~8℃, valid for 18 months. If the use period of printing on the package is not exceeded, the product can be stored stably at temperature (20℃~30℃) for 30 days. The temperature change during transportation (<37℃) has no effect on product quality. The reagent strip and the sample detection solution are used in one-to-one mode, that is, a reagent strip is matched with a bottle of sample detection solution to detect a sample. After unsealing, it can be stabilized for 1 hour at room temperature. Under normal humidity and light conditions, store and use according to the above requirements.
Interpreting results
Pepsinogen I (PGI)
Pepsinogen I concentration in blood reflects the mucosal structure and function of the gastric body (corpus). Infection with Helicobacter pylori or autoimmune disease can cause moderate to severe atrophy of stomach body mucosa (atrophic gastritis of corpus). Then follows a fall in blood pepsinogen I levels below 30 µg/l, and the associated acid-free or low-acid stomach. In contrast, if the patient has inflammation of stomach body mucosa, but no atrophy (gastritis of corpus), the blood pepsinogen I concentration tends to increase to some extent.
Pepsinogen II (PGII)
Pepsinogen II concentration in blood reflects the structure and function of whole stomach mucosa. Its concentration in blood circulation increases in the case of stomach mucosal inflammation (gastritis). In most cases the reason for this is a Helicobacter pylori infection, but sometimes other factors are involved such as some drugs, bacterial, viral or parasitic infections, biliary reflux (rise of bile acids from the intestine to the stomach), strong spices or alcohol. Values more than 10 µg/l often refer to inflammation.
Pepsinogen I/Pepsinogen II (PGI / PGII)
The Pepsinogen I/II ratio is used together with Pepsinogen I value for diagnosis of atrophy of the gastric body mucosa (atrophic gastritis of corpus). In the case of atrophic gastritis of corpus, the ratio decreases below 3.
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